The least we could do

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By Sharmika

A PRP who enjoys reading fiction (an unhealthy amount) and morning strolls.

If you’ve worked at a dispensary, be it in a government or a community setting you would know that the patients or customers (the term patient(s) will be used henceforth for convenience sake but the context applies to both parties) rely so much on the dispenser a.k.a the pharmacist to relay any and all information that they may need to know about any product but most importantly, about any medication that they will be taking. 

Of course, there is no denying the fact that for each medication, there may be more than a couple things that need to be highlighted to said patient. However, because of how fast-paced everything is nowadays, we tend to emphasise the key points to get the message across to the patients. Ideally, these work in the favour of both the messenger and receiver.

For example, for statins we counsel patients to take their dose at night and advise that muscle aches are a possible side effect of consuming the medication. Should they experience muscle aches that are affecting their daily routine, we advise them to consult the doctor at the soonest. Or for ACE inhibitors like Perindopril, patients are forewarned that dry tickly cough is a common side effect and that the medication should be administered before food. Now these two medications mentioned are quite commonly encountered as part of a patient’s chronic medication regime for dyslipidemia and hypertension respectively. But what happens when you’re suddenly expected to counsel patients for the medications that they are taking for their depression, anxiety or mood disorders among many others.

While pharmacists these days frequently come across patients on medications for their mental health disorders, very few of us are able to deliver counselling points that are of relevance to the patients. So here’s some pointers on how you can get the message across to the patient in their road to getting better because it really is the least you could do. It’s already tough enough that the patients are going through a rough patch in their life. What’s worse is if they are told to start taking some medications that apparently help them get better blindly, with no sort of explanation whatsoever. 

These are some key points that you can convey to the patients on psychiatric medications. (Keep in mind that these are not an exhaustive list of the counselling points)

A very general principle when counselling for any medication is to engage the patient in a sort of conversation/discussion. I say ‘sort of’ because I am fully aware of the fact that this is unlikely to happen should it be a day where you’ve got a long line of patients waiting. Ultimately, the goal is to ensure that the patient understands the reason he/she is taking the medication and the expected outcomes. This will improve their adherence to the medications. 

Stray away from jargons and terminologies that may scare the patients. Instead, use layman terms to get your points across. Remember, our intention is to educate the patient, not to have a sad one-sided conversation where we merely instruct the patient on how to take the medication.

Now, with that out of the way, let’s dive into some of the points you can share with the patients. (Again, this is very generalised information unless stated otherwise.)

1.Antidepressants

Indication
  • For psychiatric disorders & major depression
  • Important to ask patient → what the doctor told the medication was indicated for
    • SSRI & SNRIs → also indicated for OCD, panic disorder etc
    • Off-label uses → eg. Bupropion for smoking cessation
Onset
  • Improvement in mood symptoms (i.e depressed mood, lack of interest) → takes 3-6 weeks. It may worsen initially 
  • Immediate results → not possible, but sleep & appetite may improve within 1-2 weeks
  • Do not discontinue treatment even after symptoms improve as treatment duration varies from 6-12 months or longer, depending on the patient’s condition
Adverse effects
  • Some drugs are sedating while some are activating
  • As such, whether it should be taken in the morning or evening before bed differs
  • Some of them may cause gastrointestinal effects (i.e. nausea) or affect sexual function (i.e. anorgasmia)
  • Important to report to doctor if patient experiences any of these
Drug-food interaction
  • Consuming alcohol while on medication → worsens the sedative effects
  • Explain that the medication aims to improve mood but alcohol does the exact opposite

 

2. Antipsychotic drugs

Indication
  • Treats psychotic symptoms → common in schizophrenia & bipolar disorders
    • Example: Disconnected thoughts, delusions, hallucinations
  • Adjunctive to antidepressants → in treatment-resistant depression
Onset
  • Slow onset of effect
  • Requires several weeks → to reduce severity of symptoms ; Symptoms may worsen initially
Duration of treatment
  • Explain that bipolar disorders & schizophrenia are lifelong disorders → treatment may be for months or years to prevent recurrence ; Not only for acute symptoms
  • Advise patient to not discontinue medications on their own
Adverse effects
  • Antipsychotics vary in adverse effects
    • Dry mouth → increase fluid intake, consume ice chips or hard candy
    • Dry eyes → use eye lubricants/moisturisers
    • Constipation → increase fluid & dietary fibre intake and lead an active lifestyle
    • May switch to lower risk agents → Olanzapine, Aripiprazole, Sulpiride
    • Sedating → Clozapine, Olanzapine, Quetiapine → Do not drive/handle any machinery
    • Anticholinergic effects (i.e. Dry mouth, blurred vision, constipation) → Clozapine (higher), Olanzapine, Quetiapine
    • Agranulocytosis (ANC <100/mm3) orSevere neutropenia (ANC <500/mm3) → Clozapine prominently ; So, baseline & regular ANC monitoring is required
    • Orthostatic hypotension → Clozapine (higher), Ripseridone, Quetiapine ; Counsel elderly patient to not rise quickly from sitting or lying down position without assistance
    • Weight gain → Clozapine & Olanzapine (higher), Risperidone, Quetiapine ; First sign is increased appetite, recommend healthy diet & exercise
Image sourced from fherehab.com

3. Anti-anxiety drugs

Indication
  • Important to differentiate → symptoms of anxiety & primary anxiety disorders (i.e PTSD, generalised anxiety disorder, OCD)
  • Anxiety 
    • Brief → triggered by stressful situations
    • Secondary consequence of psychiatric & medical conditions 
  • Primary anxiety disorders → distinct drug treatment for each; mostly antidepressants
Onset
  • Primary anxiety disorder → sedation is not a required effect 
    • Eg. Fluoxetine → effective for many anxiety disorders but is not sedative
  • Panic disorders → Benzodiazepines (BDZ) & antidepressants are effective with different onsets
    • BDZ (i.e Alprazolam, Clonazepam) → within 1-2 weeks, reduces panic attacks
    • Antidepressants (i.e Paroxetine, Sertraline) → requires 2-3 months to take effect
    • May encounter patient started on both BDZ & antidepressants → if they have 2-3 panic attacks/week
  • Symptoms of anxiety → sedation may be required & fast onset
Duration of treatment
  • Usually for a long period of time
    • Antidepressants → maintenance therapy to prevent recurrence of symptoms
    • BDZ → short term usage for acute symptoms ; due to dependence risk
Adverse effects
  • BDZ → impaired ability & judgement when operating machinery, excessive sedation, dizziness
    • Higher potency → Alprazolam & Lorazepam → interferes with memory 
  • Antidepressants (in primary anxiety disorders) → initial worsening of symptoms 
    • So, patients are started on lower doses than that for depression
Key points
  • First time BDZ users
    • Counsel on → unpredictable degree of initial sedation
    • Caution when driving → when first started/if dose is titrated up
    • Reassure that addiction risk → low if on prescribed dose
  • Addiction vs Dependence
    • Addiction → Taking doses that is higher than prescribed dose
    • Dependence → Body accustomed to presence of drug & so, can’t discontinue it suddenly after continued use
      • Advise to not skip doses/stop treatment on their own
      • Dose changes must be done at prescriber’s discretion
Image sourced from lanceschaubert.org

4. Hypnotic drugs

Indication
  • Typically used for insomnia
    • Eg. Non-BDZ hypnotic → Zolpidem 
Onset
  • Rapid onset → within 30 minutes
    • Zolpidem 
      • variable duration of effect , 3-8 hours
      • Discontinuation → not associated with rebound effects
  • Advise to take only when ready to go to bed
  • Not advisable to do other activities i.e taking a shower, after taking hypnotics
Duration of treatment
  • Approved for short-term use
    • Clinical studies in sleep laboratories → done for several weeks to months
Adverse effects
  • Effects associated with → drug’s dose & pharmacokinetic properties
  • Examples:
    • Morning sedation
    • Anterograde amnesia → unable to store new memories
    • Impaired balance & higher risks of falls → especially in elderly
    • Complex sleep-related behaviour → eg. Sleepwalking, Sleep-related eating/driving
    • Rebound insomnia
    • Withdrawal
    • Dependence
Key points
  • Counsel on sleep hygiene
    • Set a regular time to sleep & wake up
    • Use bed only for sleep → Avoid using it for eating, reading etc.
    • Create comfortable environment for sleep → Reduce noise, light & other distracting activities
    • To avoid:
      • Naps during the day
      • Alcohol, caffeine, large meals & fluids just before bed
      • Exercising before bedtime
      • Taking any activating medications before bed
  • If patients find their current dose ineffective/want to stop their treatment
    • Counsel that dosage changes & discontinuation of drug → consult with prescriber

5. Mood stabilisers

Indication
  • Aids in improving symptoms & reducing frequency of future episodes (i.e for bipolar disorders, involving mania and depressive episodes)
Blood level monitoring
  • Periodically, patient’s drug blood level has to be monitored → ensures that the optimal dosing is prescribed & benefits and adverse effects can be maximised and minimised respectively
Adverse effects
  • Lithium – nausea, diarrhoea, fine hand tremor, lethargy, slurred speech, hypothyroidism, weight gain
    • Drink plenty of fluids to avoid dehydration
    • Frequent urination is likely
    • Maintain consistent salt intake → to ensure Lithium level in body isn’t affected
    • Avoid caffeine in coffee & tea → as it increase Lithium excretion from body
    • Talk to the doctor as soon as possible if patient is pregnant or are planning a pregnancy while on this medication 
  • Sodium valproate – nausea, diarrhoea, sedation, tremor, transient hair loss, weight gain
    • May cause drowsiness → do not drive/operate heavy machinery 
    • Thrombocytopenia → may lead to unusual bruising/bleeding that can’t be stopped
    • Shouldn’t be taken during pregnancy → use a reliable form of birth control while on this medication
  • Assure patient → if drug’s blood level is monitored & dose is optimised accordingly → adverse effects are less likely to occur
Counselling based on symptoms
  • Explain on how it helps their manic/depressive episode symptoms such as:
    • Aids in social functioning
    • Subdues excessive energy & irritability
    • Reduces high risk behaviours i.e excessive spending
Image sourced from Getty Images

This information is merely a drop in the vast ocean. Nevertheless, they are meant to guide the patients and reassure them when they are told to take a supposed medication that will help them in one way or another.

Be mindful that as pharmacists, we aren’t supposed to be merely stating facts when counselling the patient. Addressing any concerns and questions as well as being able to discuss any psychiatric symptoms or adverse effects with the patient is the ideal pharmacist’s role. You never know, this medication counselling that the patient receives, may support their treatment journey positively. And in the long run, that’s what all of us want, isn’t it? To help those in need, even if it’s the least we could do.

 

References

  1. Stimmel, G. (2015) Counseling Patients on Medication For Adult Psychiatric Disorders. Available at: https://www.ncpa.co/issues/APOCT15-CE.pdf (Accessed: 2 November 2023).
  2. ‌“Antidepressants: 10 Things You Should Know.” NPS MedicineWise, Australian Commission on Safety and Quality in Health Care, 27 Apr. 2022, www.nps.org.au/consumers/antidepressants-10-things-you-should-know.

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